Never-ending research and convergence for regeneration

CureNology pursues biomedical innovation through ECM technology, which can regenerate various organs without systemic side effects.

Core Technology 1

Extracellular Matrix (ECM) Technology

Scientific Basis

Human tissue consists of tissue-specific cell types and protein composition (ECM). ECM performs multiple functions

• Tissue structure maintenance

• Signaling molecule reservoir

• Cascading biomechanical signal association

Importance of ECM

ECM damage or composition change causes diseases or function loss. It can be a safe target for disease treatment as the very end product of biosynthesis, with no systematic impact.

CureNology's Innovation

CureNology uses cells originated from the same tissue type (i.e. dermal & epidermal cells for skin application) to produce ECM with optimal composition for functional tissue regeneration.

This approach is manufacturable, saleable, quality-controlled, and applicable to a wide variety of diseases.

What is an ECM?
Compare with Honey comb vs. human tissue

Human tissue

ECM is a protein complex of human cells. it consists of about 300 protein types, signaling molecules, growth factors, and cytokines

• Produced by cells

• Structure support

• Each cell type produces uniquely composed ECM

• Compositional change leads to tissue malfunction

• i.e. Scar: overproduction of collagen type I No normal skin function

Honey comb

Consists of various components such as royal jelly, pollen, and propolis, and thus contains a large number of bioactive ingredients, such as polyphenols and flavonoids.

• Produced by honey bees

• Structure support

• Functions as living environment

• Provides Nutrition

Extracellular Matrix (ECM) Technology for REVERSE AGING

Reversing skin aging is to change skin protein composition

Restoring Elastin and Collagen III content by providing

• Various growth factors stimulate such protein production

• Provide such protein directly

ECM, especially Elastin and Collagen III from the same but young human skin cells can reverse skin aging by restoring young skin protein composition

Young skin
Rich in Elastin and Collagen III

Aged skin
Reduced Elastin and collagen III but Rich in collagen I. Reduced elasticity and increased wrinkles. Longer recovery time from any type of damage

● Elastin ● Collagen III ● Collagen I

CureNology's Innovation

Currently, there is no commercialized reverse aging agent by directly provides young skin ECM to change skin composition from aged condition to young & healthy condition.

Only CureNology’s ECM technology can mass-produce such ECM complexes from human skin cells or stem cell 3D culture

Culture Circumstance

Cell Species

Culture medium

Only CureNology’s ECM technology

ECM complexes Mass Production

Core Technology 2

Stem Cell Secretome Technology

Scientific Basis

Stem cells secrete a uniquely composed Secretome depending on the physicochemical growth environment. This Secretome contains peptides, proteins, cytokines, growth factors, and exosomes that support tissue development or regeneration.

Advantages

This technology is manufacturable with conventional bio-facilities, saleable, quality controlled, and applicable to a wide variety of diseases.

CureNology's Innovation

CureNology's 3D culture environment offers an optimized growth environment for stem cell secretome composition applicable to skin health. CureNology has developed a bio-physiochemical environment tuning technology to optimize the growth environment for various cell types.

Stem cell Secretome promotes

• Fast young cell population increase

• Synthesis of proteins that are critical for young skin

• Healing of UV damaged (aging) cells to become normal healthy skin cells

Core Technology 3

Transdermal Delivery Technology

Scientific Basis

In spite of its unique benefit, the part of the Stem cell Secretome cannot pass the skin barrier due to its large molecule size. The transdermal delivery system efficiently enhances stem cell secretome delivery to the deep dermal region

Advantages

Each herb is renowned for its therapeutic effects, rooted in a millennium of Korean traditional medicine. This botanical-based system carries its own potent ingredients, synergizing with the secretome to amplify the reverse-aging potential of both the herbs and the secretome.

CureNology's Innovation

CureNology developed a Transdermal Delivery System (TDS) that harnesses the unique collective power of Mystic Eight Herbs. This Transdermal Delivery System effectively delivers Stem Cell Secretome without disturbing the skin barrier.

Mystic Eight Herbs derived Transdermal Delivery System

Water soluble micro-spear

Scientific Basis

Gentle exfoliation and temporary micro-pore formation can enhance the efficacy of the Transdermal Delivery System.
However, any agent used for these purposes is supposed not to exert any harmful side effects.

Advantages

Soluble micro-spears can be dissolved and completely absorbed into the skin. Gentle exfoliation also promotes faster skin turnover cycles to accelerate skin renewal.

CureNology's Innovation

CureNology developed a soluble micro-spear that can gently exfoliate and create temporary micro-pores to open physical channels to guide the Transdermal Delivery System carrying the Stem Cell Secretome to the deep dermal skin region.

Patented

Patented

Learn more about
CureNology highlight

Learn more about
CureNology Philosophy

Be our partner
Contact us