Scientific Basis
Human tissue consists of tissue-specific cell types and protein composition (ECM). ECM performs multiple functions.
- Tissue structure maintenance
- Signaling molecule reservoir
- Cascading biomechanical signal association
Core
Technologies
Technologies
We challenge skin & organ regeneration based on our unrivaled and unique technological prowess.
Never-ending research and convergence for regeneration
CureNology pursues biomedical innovation through ECM technology, which can regenerate various organs without systemic side effects.
Extracellular MatrixStem Cell SecretomeTransdermal delivery
Importance of ECM
ECM damage or composition change causes diseases or function loss. It can be a safe target for disease treatment as the very end product of biosynthesis, with no systematic impact.
CureNology's Innovation
CureNology uses cells originated from the same tissue type (i.e. dermal & epidermal cells for skin application) to produce ECM with optimal composition for functional tissue regeneration.
This approach is manufacturable, scalable, quality-controlled, and applicable to a wide variety of diseases.
What is an ECM?
Compare with Honey comb vs. human tissue
Human tissue
ECM is a protein complex of human cells. It consists of about 300 protein types, signaling molecules, growth factors, and cytokines.
- Produced by cells
- Structure support
- Each cell type produces uniquely composed ECM
- Compositional change leads to tissue malfunction
- i.e. Scar: overproduction of collagen type I No normal skin function
Honey comb
Consists of various components such as royal jelly, pollen, and propolis, and thus contains a large number of bioactive ingredients, such as polyphenols and flavonoids.
- Produced by honey bees
- Structure support
- Functions as living environment
- Provides Nutrition
Extracellular Matrix (ECM) Technology
for REVERSE AGING
Reversing skin aging is to change skin protein composition
Restoring Elastin and Collagen III content by providing
- Various growth factors stimulate such protein production
- Provide such protein directly
ECM, especially Elastin and Collagen III from the same but young human skin cells can reverse skin aging by restoring young skin protein composition.
CureNology's Innovation
Currently, there is no commercialized reverse aging agent by directly providing young skin ECM to change skin composition from aged condition to young and healthy condition.
Only CureNology's ECM technology can mass-produce such ECM complexes from human skin cells or stem cell 3D culture.
Cell
SpeciesCulture
CircumstanceCulture
mediumECM complexes
Mass ProductionOnly CureNology's ECM technology
SpeciesCulture
CircumstanceCulture
mediumECM complexes
Mass ProductionOnly CureNology's ECM technology
Scientific Basis
Stem cells secrete a uniquely composed Secretome depending on the physicochemical growth environment. This contains proteins, peptides, cytokines, growth factors, and exosomes.
Advantages
This technology is manufacturable with commercial bio-facilities, scalable, quality controlled, and applicable to a wide variety of diseases.
CureNology's Innovation
CureNology's 3D culture environment offers an optimized growth environment for stem cell secretome composition applicable to skin health. CureNology has developed a bio-physicochemical environment tuning technology to optimize the growth environment for various cell types.
Stem cell Secretome promotes
- Fast young cell population increase
- Synthesis of proteins that are critical for young skin
- Healing of UV damaged (aging) cells to become normal healthy skin cells
Mystic Eight Herbs derived Transdermal Delivery System
In spite of its unique benefit, the part of the Stem Cell Secretome cannot pass the skin barrier due to its large molecule size. The transdermal delivery system efficiently enhances stem cell secretome delivery to the deep dermal region.
Advantages
Each herb is renowned for its therapeutic effects, rooted in a millennium of Korean traditional medicine. This botanical-based system carries its own potent ingredients, synergizing with the secretome to amplify the reverse-aging potential of both the herbs and the secretome.
CureNology's Innovation
CureNology developed a Transdermal Delivery System that effectively delivers Stem Cell Secretome without disturbing the skin barrier.
Water soluble micro-spear
Gentle exfoliation and temporary micro-pore formation can enhance the efficacy of the Transdermal Delivery System. However, any agent used for these purposes is supposed not to exert any harmful side effects.
Patented Advantages
Soluble micro-spears can be dissolved and completely absorbed into the skin. Gentle exfoliation also promotes faster skin turnover cycles to accelerate skin renewal.
CureNology's Innovation
CureNology developed a soluble micro-spear that can gently exfoliate and create temporary micro-pores to open physical channels to guide the Transdermal Delivery System carrying the Stem Cell Secretome to the deep dermal skin region.
